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Scientists Reveal the Secret to a Unusual Animal’s Everlasting Youth

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November 14, 2022
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Cross-section by a tentacle of a transgenic sea anemone exhibiting differentiation merchandise of the SoxC cell inhabitants (magenta) and retractor muscular tissues (yellow). Credit score: Andreas Denner

In sea anemones, extremely conserved genes assure the lifelong differentiation of neurons and glandular cells.

Sea anemones are seemingly immortal animals. They appear to be proof against getting old and the adverse impacts that people expertise over time. Nonetheless, the precise causes for his or her everlasting youth should not fully understood. 

The genetic fingerprint of the ocean anemone Nematostella vectensis reveals that members of this extremely historical animal phylum make use of the identical gene cascades for neural cell differentiation as extra advanced organisms. These genes are additionally accountable for sustaining the steadiness of all cells within the organism in the course of the anemone’s lifetime. These findings had been lately revealed within the journal Cell Stories by a group of developmental biologists headed by Ulrich Technau of the College of Vienna.

Virtually all animal organisms are made up of thousands and thousands, if not billions, of cells that be a part of collectively in intricate methods to create particular tissues and organs, that are made up of a spread of cell sorts, comparable to quite a lot of neurons and gland cells. Nonetheless, it’s unclear how this essential steadiness of various cell sorts emerges, how it’s regulated, and if the completely different cell varieties of completely different animal organisms have a typical origin.

Optical Longitudinal Section of a Sea Anemone

Optical longitudinal part of a sea anemone with nanos1-transgenic neuronal cells (pink) in each cell layers. Muscle tissues are stained inexperienced, cell nuclei in blue. Credit score: Andreas Denner

Single-cell fingerprint results in frequent ancestors

The analysis group, led by evolutionary developmental biologist Ulrich Technau, who can be head of the Single Cell Regulation of Stem Cells (SinCeReSt) analysis platform on the College of Vienna, has deciphered the range and evolution of all nerve and gland cell sorts and their developmental origins within the sea anemone Nematostella vectensis.

So as to obtain this, they used single cell transcriptomics, a way that has revolutionized biomedicine and evolutionary biology over the previous decade.

“With this, complete organisms may be resolved into single cells – and the whole lot of all at the moment expressed genes in every particular person cell may be decoded. Totally different cell sorts essentially differ within the genes they categorical. Due to this fact, single cell transcriptomics can be utilized to find out the molecular fingerprint of every particular person cell,” explains Julia Steger, the primary writer of the present publication.

Within the examine, cells with an overlapping fingerprint had been grouped. This allowed the scientists to differentiate outlined cell sorts or cells in transitional levels of growth, every with distinctive expression combos. It additionally allowed the researchers to determine the frequent progenitor and stem cell populations of the completely different tissues.

To their shock, they discovered that opposite to earlier assumptions, neurons, glandular cells, and different sensory cells originate from one frequent progenitor inhabitants, which could possibly be verified by genetic labeling in dwelling animals. Since some gland cells with neuronal features are additionally identified in vertebrates, this might point out a really outdated evolutionary relationship between gland cells and neurons.

Historical genes in fixed use

One gene performs a particular position within the growth of those frequent ancestor cells. SoxC is expressed in all precursor cells of neurons, gland cells, and cnidocytes and is important for the formation of all these cell sorts, because the authors had been moreover in a position to present in knockout experiments.

“Curiously, this gene isn’t any stranger: It additionally performs an necessary position within the formation of the nervous system in people and lots of different animals, which, along with different knowledge, exhibits that these key regulatory mechanisms of nerve cell differentiation appear to be conserved throughout the animal kingdom,” says Technau.

By evaluating completely different life levels, the authors additionally discovered that in sea anemones, the genetic processes of neuron growth are maintained from the embryo to the grownup organism, subsequently contributing to the steadiness of neurons all through the lifetime of Nematostella Vectensis.

That is outstanding as a result of, in contrast to people, sea anemones can change lacking or broken neurons all through their lives. For future analysis, this raises the query of how the ocean anemone manages to keep up these mechanisms, which in additional advanced organisms solely happen within the embryonic stage, into the grownup organism in a managed method.

Reference: “Single-cell transcriptomics identifies conserved regulators of neuroglandular lineages” by Julia Steger, Alison G. Cole, Andreas Denner, Tatiana Lebedeva, Grigory Genikhovich, Alexander Ries, Robert Reischl, Elisabeth Taudes, Mark Lassnig and Ulrich Technau, 20 September 2022, Cell Stories.
DOI: 10.1016/j.celrep.2022.111370





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